Regenerative Surgery

Nanofat grafting

Your own fat, emulsified until nothing remains of its structure — injected not to add volume, but to change the quality of the skin above it.

Lead — operative or clinical setting
2.4:1 · 2400px wide min
no identifiable patient
What it is

Fat is harvested from the abdomen or thigh through a small cannula, then mechanically emulsified — passed back and forth between syringes and filtered — until the fat cells themselves are broken down. What is left is a thin fluid containing the stromal vascular fraction: the regenerative cell population that lives among fat cells rather than the fat cells themselves.

Because it holds no intact adipocytes, nanofat does not add volume and is not a filler. It is placed superficially, in the dermis and just beneath it, where the intention is to influence skin quality — fine crepey texture, discolouration under the eyes, the surface of a mature scar. Where volume is the goal, structural fat grafting is the different procedure, and the two are often planned together in the same session.

The technique was described by Dr. Patrick Tonnard and Dr. Alexis Verpaele, whose aesthetic fellowship Dr. Cruz completed from March to June 2025, training with them in Ghent and at E:MC2 in Sint-Martens-Latem, Belgium.

A candid note on evidence: nanofat is well established in surgical practice and has a coherent biological rationale, but the published outcome data is smaller and shorter-term than for long-standing procedures. Results vary between people, and the degree of change is generally subtle rather than dramatic. Any surgeon who promises you a specific result from it is overstating what is known.

Provenance

The technique described in Ghent

Nanofat grafting was developed and published by Dr. Patrick Tonnard and Dr. Alexis Verpaele. Dr. Cruz trained under both during his fellowship with them, March to June 2025, in Ghent and at E:MC2 in Sint-Martens-Latem, Belgium.

Illustration — emulsification and filtration sequence
line-art · ink + jaguar green
can be drawn to match the site
Detail — harvest cannula or filter set
3:2 · 2000px min · macro
Start to Finish

How it runs

I
Assessment
Whether nanofat is the right tool depends on what is bothering you. Skin texture and discolouration may respond; volume loss and deep folds need a different procedure. [WHAT IS ASSESSED AT CONSULT].
II
Harvest
A small volume of fat is taken through a fine cannula, usually from the abdomen or inner thigh, under [ANAESTHESIA TYPE]. The donor site needs only a puncture.
III
Processing and injection
The fat is emulsified and filtered at the operating table, then injected superficially into the treatment area with a fine needle or blunt microcannula. Typical session [TYPICAL DURATION].
IV
Recovery and review
Expect swelling and bruising for [EXPECTED DOWNTIME]. Change in skin quality appears gradually over weeks to months rather than immediately. Review at [FOLLOW-UP SCHEDULE].
Anaesthesia
[ANAESTHESIA TYPE]
Time in theatre
[TYPICAL DURATION]
Back to normal
[EXPECTED DOWNTIME]
Related
Structural fat grafting
Volume restoration with intact fat, often planned in the same session.
MACS Facelift
Nanofat is frequently combined with a facelift to address skin quality the lift cannot.
Regenerative Surgery
How tissue-supportive technique connects the reconstructive and aesthetic sides of the practice.

Discuss whether this is right for you

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Dr. Pacifico Cruz Board-certified plastic surgeon — reconstructive microsurgery and aesthetic facial rejuvenation.
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Locations St. Luke's Medical Center, BGC Cardinal Santos Medical Center
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© 2026 Dr. Pacifico Cruz, MD. Information on this site is for general purposes and does not constitute medical advice.